Drugs & Vitamins

Quinapril and Hydrochlorothiazide Active Ingredients: Quinapril and Hydrochlorothiazide Representative Names: Accuretic, Quinaretic Available Product Images: What are quinapril-hydrochlorothiazide tablets? What should I tell my health care provider before I take this medicine? How should I use this medicine? What if I miss a dose? What drug(s) may interact with quinapril-hydrochlorothiazide? What side effects may I notice from taking quinapril-hydrochlorothiazide? What should I watch for while taking quinapril-hydrochlorothiazide? Where can I keep my medicine? What are quinapril-hydrochlorothiazide tablets? (Back to top) QUINAPRIL-HYDROCHLOROTHIAZIDE (Accuretic®, Quinaretic™) is a combination of two drugs used to lower blood pressure. Quinapril is an ACE inhibitor that controls high blood pressure (hypertension) by relaxing blood vessels. Hydrochlorothiazide is a diuretic. High blood pressure can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. By lowering blood pressure, quinapril-hydrochlorothiazide can help reduce your risk of having damage to your kidneys, heart, or other organs. This medicine does not cure high blood pressure. Generic quinapril-hydrochlorothiazide tablets are available. What should I tell my health care provider before I take this medicine? (Back to top) They need to know if you have any of these conditions: •autoimmune disease (e.g., lupus), or suppressed immune function •previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat (angioedema) •bone marrow disease •diabetes mellitus •gout •heart or blood vessel disease •liver disease •recent heart attack or stroke •kidney disease, (e.g. renal failure or renal artery stenosis) •pancreatitis •electrolyte imbalance (e.g. low or high levels of potassium in the blood) •if you are on a special diet, such as a low-salt diet (e.g. using potassium substitutes) •sulfonamide (sulfa) or thiazide allergy •an unusual or allergic reaction to quinapril, hydrochlorothiazide, other medicines, foods, dyes, or preservatives •pregnant or trying to get pregnant •breast-feeding How should I use this medicine? (Back to top) Take quinapril-hydrochlorothiazide tablets by mouth with or without food. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine except on your prescriber's advice. Many patients with high blood pressure will not notice any signs of the problem. Therefore, it is very important that you take this medicine exactly as directed and that you keep your appointments with your prescriber or health care professional even if you feel well. Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. What if I miss a dose? (Back to top) If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. What drug(s) may interact with quinapril-hydrochlorothiazide? (Back to top) •allopurinol •aminolevulinic acid •antiinflammatory drugs (NSAIDs such as ibuprofen) •aspirin •azathioprine •blood pressure medications •calcium supplements •cholesterol-lowering medications (e.g. cholestyramine or colestipol) •medicines for diabetes •dofetilide •gold compounds, often used for arthritis •hawthorn •lithium •methoxsalen •monoamine oxidase inhibitors (Azilect®, Eldepryl®, Emsam®, Marplan®, Nardil®, Parnate®, Zelapar™) •porfimer •potassium salts or potassium supplements •tetracycline •water pills (especially potassium-sparing diuretics such as triamterene or amiloride) Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines. What side effects may I notice from taking quinapril-hydrochlorothiazide? (Back to top) Side effects that you should report to your prescriber or health care professional as soon as possible: Rare or uncommon: •difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat •redness, blistering, peeling or loosening of the skin, including inside the mouth •swelling of your face, lips, tongue, hands, or feet •unusual rash, bleeding or bruising, or pinpoint red spots on the skin •decreased sexual function Other: •confusion, dizziness, lightheadedness or fainting spells •decreased amount of urine passed •fast or uneven heart beat, palpitations, or chest pain •fever or chills •irregular heartbeat •muscle cramps •stomach pain •vomiting •unusual tiredness or weakness •worsened gout pain •yellowing of the eyes or skin Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): •cough •diarrhea •increased sensitivity to the sun •nausea •tiredness or fatigue What should I watch for while taking quinapril-hydrochlorothiazide? (Back to top) Check your blood pressure regularly while you are taking quinapril-hydrochlorothiazide. Ask your prescriber or health care professional what your blood pressure should be and when you should contact him or her. When you check your blood pressure, write down the measurements to show your prescriber or health care professional. You must not get dehydrated, ask your prescriber or health care professional how much fluid you need to drink a day. If you are taking this medicine for a long time you must visit your prescriber or health care professional for regular checks on your progress. Make sure you schedule appointments on a regular basis. Check with your prescriber or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take quinapril-hydrochlorothiazide. You may get dizzy. Do not drive, use machinery, or do anything that requires mental alertness until you know how quinapril-hydrochlorothiazide affects you. To avoid dizzy or fainting spells, do not stand or sit up quickly. Alcohol may increase the possibility of dizziness. Avoid alcoholic drinks until you have discussed their use with your prescriber or health care professional. If you are going to have surgery tell your prescriber or health care professional that you are taking quinapril-hydrochlorothiazide. Quinapril-hydrochlorothiazide may affect your blood sugar level. If you have diabetes, check with your prescriber or health care professional before changing the dose of your diabetic medicine. Avoid salt substitutes unless you are told otherwise by your prescriber or health care professional. Do not take medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems without asking your prescriber or health care professional for advice. Do not treat yourself for a fever or sore throat; check with your prescriber or health care professional first. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Where can I keep my medicine? (Back to top) Keep out of the reach of children. Store at room temperature below 20—25 degrees C (68—77 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date. Last Updated:03/23/2007 CLINICAL PHARMACOLOGY© GOLD STANDARD MULTIMEDIA INC, ALL RIGHTS RESERVED

Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It should not be construed to indicate that the use of the product is safe, appropriate, or effective for you. Consult your healthcare professional before taking the product.